Multiphysics Modelling of Background Dose by Systemic Targeted Alpha Therapy
نویسندگان
چکیده
منابع مشابه
Background Dose for Systemic Targeted Alpha Therapy
The phase 1 clinical trial of systemic Targeted Alpha Therapy for metastatic melanoma has shown that solid tumours can be regressed by alpha radiation. However, patient blood vessels and lymphocytes inevitably received a background radiation from non-targeted alpha decays in the blood circulation. To determine the toxicity of alpha particle to normal tissue capillaries and peripheral blood lymp...
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متن کاملsystemic targeted alpha radiotherapy for cancer
background: the fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.the high linear energy transfer (let) of alpha radiation to the targeted cancer cellscauses double strand breaks in dna. at the same time, the short range radiation spares adjacent normal tissues. this targeted approach complements conventional external beam radiotherapy and ch...
متن کاملSystemic Targeted Alpha Radiotherapy for Cancer
BACKGROUND The fundamental principles of internal targeted alpha therapy forcancer were established many decades ago.The high linear energy transfer (LET) ofalpha radiation to the targeted cancer cellscauses double strand breaks in DNA. Atthe same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and chemot...
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Targeted therapies use an understanding of the pathophysiology of a disease in an individual patient. Although targeted therapy for systemic sclerosis (SSc, scleroderma) has not yet reached the level of patient-specific treatments, recent developments in the understanding of the global pathophysiology of the disease have led to new treatments based on the cells and pathways that have been shown...
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ژورنال
عنوان ژورنال: Journal of Medical Imaging and Radiation Sciences
سال: 2018
ISSN: 1939-8654
DOI: 10.1016/j.jmir.2018.06.002